Dynamics of human cardiogenesis and its disruption in trisomy 21

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11125-y

Single-cell and spatial multiomics are combined to define niches in the developing human heart, revealing pacemaker-cell organization, cardiomyocyte maturation and compaction, and developmental perturbations associated with trisomy 21.